Parijat Ghosh Patrick Dempsey is swapping charm for chaos in the upcoming crime drama Memory of a Killer. Fans know him as McDreamy from Grey’s Anatomy, but this time he goes full gritty as a hitman whose toughest enemy might be his own brain. The new series drops its first episodes starting January 25 and January 26, 2026, on Fox, and the trailer has already stirred up a lot of buzz online.
What Is Memory of a Killer?
Memory of a Killer is an American crime drama series developed by Ed Whitmore and Tracey Malone. It is inspired by the Belgian story De Zaak Alzheimer from 2003. The show blends intense crime action with emotional drama about memory loss, family, and identity.
The plot centers on Angelo Ledda, played by Patrick Dempsey. Angelo is a professional hitman who lives two lives. By day he pretends to be a quiet father and a photocopier salesman in upstate New York. By night he carries out deadly assignments in New York City. Everything changes when he is diagnosed with early-onset Alzheimer’s. As his memory slips, his past catches up with him, and threats to his family escalate fast.
Dempsey’s Bold New Role
This role marks a dramatic shift for Dempsey. He gained fame playing suave, caring characters like neurosurgeon Derek Shepherd. In Memory of a Killer he plays someone darker and more unpredictable. The show challenges him with complex emotions, action scenes, and a storyline that forces the character to fight both external enemies and his own failing mind.
Fans have reacted strongly online to the trailer. They are calling this one of Dempsey’s boldest roles yet, and the stark contrast between his early career and this project is part of the appeal. It’s like watching your favorite cozy doctor suddenly discover a Glock in his glove compartment.
A Cast You Should Know
Dempsey is not alone in Memory of a Killer. The series also stars:
- Michael Imperioli as Dutch, a chef and crime boss who employs Angelo.
- Richard Harmon as Joe, another hitman connected to Angelo’s world.
- Odeya Rush as Maria, Angelo’s pregnant daughter who becomes a key part of the emotional stakes.
- Daniel David Stewart as Jeff, Maria’s husband.
- Peter Gadiot as Dave, a local detective with his own motivations.
- Gina Torres appears as Special Agent Linda Grant, adding law enforcement pressure to the mix.
Where to Watch Memories of A Killer
Fox is giving Memory of a Killer a special two-night launch. The first episode airs Sunday, January 25, 2026, soon after the NFC Championship Game. The official regular timeslot episode follows Monday, January 26, at 9 PM Eastern Time. Hulu will stream the series soon after its television debut.
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